The authors present 54 cases histories of therapeutic terminations of pregnancy. The mean age of the patients was 28.6 years at the time of diagnosis with the following in indications for the antenatal diagnosis in order of decreasing frequency: clinical history, age of the mother, seropositive for toxoplasmosis or rubella, a high fetal alpha protein level and ultrasound signs. They highlight the usefulness of ultrasound in reaching a decision as to whether pregnancy should be terminated (as it was in 25 cases out of 49) and the predominance of diagnoses of karyotype abnormalities. They also compare the various prostaglandin s used in this study (analogs of PGE1 and PGE2, diniprost). Their results, in accordance with the literature were good for gemeprost and sulprostone with expulsion in 29 out of 32 cases within 24 hours and in 9 cases out of 11 within 20 hours respectively.