Slit diaphragm junctional complex and regulation of the cytoskeleton

Puneet Garg; Rakesh Verma; Lawrence B Holzman

doi:10.1159/000101795

Slit diaphragm junctional complex and regulation of the cytoskeleton

Nephron Exp Nephrol. 2007;106(2):e67-72. doi: 10.1159/000101795. Epub 2007 Jun 6.

Authors

Puneet Garg¹, Rakesh Verma, Lawrence B Holzman

Affiliation

¹ Division of Nephrology, University of Michigan Medical School, Ann Arbor, MI 48109-0676, USA.

PMID: 17570942
DOI: 10.1159/000101795

Abstract

In recent years, identification of proteins found at the slit diaphragm has greatly improved our understanding of the molecular mechanisms responsible for forming and maintaining the glomerular filtration barrier. This review examines the function of proteins identified at the podocyte intercellular junction in coordinating podocyte intercellular junction dynamics or cytoskeletal dynamics.

Publication types

Review

MeSH terms

Animals
Cytoskeletal Proteins / metabolism*
Cytoskeleton / metabolism*
Epithelial Cells / metabolism*
Glomerular Basement Membrane / metabolism*
Humans
Intercellular Junctions / metabolism*
Membrane Proteins / metabolism*
Podocytes / metabolism*

Substances

Cytoskeletal Proteins
Membrane Proteins