Serum levels of IgG to the peptide of HCV1b core at positions 35-44 correlated with persistent infection, while levels of IgG to the peptide of NS5A at positions 2132-2140 correlated with better prognosis in HCV-infected patients

Med Microbiol Immunol. 2007 Sep;196(3):157-64. doi: 10.1007/s00430-007-0038-1. Epub 2007 Feb 16.

Abstract

We previously reported that two IgG Abs to the hepatitis C virus (HCV), anti-core 35-44 (C35) and anti-NS5A 2132-2140 (NS5A2132), existed in the sera of the majority of patients with HCV infection. This study investigated if measuring the two Abs would facilitate the prediction of a patient's prognosis. The serum levels of anti-C35 were found to correlate with persistent infection, while those of anti-NS5A2132 correlated with a better prognosis in HCV-infected patients. These results suggest that sequential measurement of the two Abs together may provide new information for the prediction of prognosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antibodies, Viral / blood*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Hepacivirus / immunology*
  • Hepatitis C / diagnosis*
  • Humans
  • Immunoglobulin G / blood*
  • Male
  • Middle Aged
  • Prognosis
  • Viral Core Proteins / immunology*
  • Viral Nonstructural Proteins / immunology*

Substances

  • Antibodies, Viral
  • Immunoglobulin G
  • Viral Core Proteins
  • Viral Nonstructural Proteins
  • nucleocapsid protein, Hepatitis C virus
  • NS-5 protein, hepatitis C virus