Cytomegalovirus (CMV) infection is a frequent disease in immunocompromised patients and can affect the gastrointestinal tract in 50% of patients, giving rise to colitis due to CMV. However, a perforated jejunum is not frequent. We present the case of an immunocompromised patient who was diagnosed with colitis due to CMV infection after bowel perforation. Outcome was favorable after surgery and antiviral treatment.