IA in play

Neuron. 2007 Jun 21;54(6):850-2. doi: 10.1016/j.neuron.2007.06.008.

Abstract

Everyone agrees about how long-term potentiation (LTP) is induced-NMDA receptor activation-but much remains to be learned about how the increase in the strength of a synaptic connection between two neurons is expressed. In this issue of Neuron, Kim et al. report a new form of NMDAR-dependent plasticity that may contribute to LTP: internalization of postsynaptic Kv4.2 potassium channels that mediate transient IA-type outward current in dendrites.

Publication types

  • Comment

MeSH terms

  • Animals
  • Dendrites / physiology*
  • Neuronal Plasticity / physiology*
  • Receptors, N-Methyl-D-Aspartate / physiology
  • Shal Potassium Channels / physiology*

Substances

  • Receptors, N-Methyl-D-Aspartate
  • Shal Potassium Channels