Linear matrix inequalities approach to reconstruction of biological networks

IET Syst Biol. 2007 May;1(3):164-73. doi: 10.1049/iet-syb:20060054.

Abstract

The general problem of reconstructing a biological interaction network from temporal evolution data is tackled via an approach based on dynamical linear systems identification theory. A novel algorithm, based on linear matrix inequalities, is devised to infer the interaction network. This approach allows to directly taking into account, within the optimisation procedure, the a priori available knowledge of the biological system. The effectiveness of the proposed algorithm is statistically validated, by means of numerical tests, demonstrating how the a priori knowledge positively affects the reconstruction performance. A further validation is performed through an in silico biological experiment, exploiting the well-assessed cell-cycle model of fission yeast developed by Novak and Tyson.

MeSH terms

  • Algorithms*
  • Artificial Intelligence*
  • Computer Simulation
  • Gene Expression Profiling / methods*
  • Gene Expression Regulation / physiology*
  • Linear Models
  • Models, Biological
  • Proteome / metabolism*
  • Signal Transduction / physiology*

Substances

  • Proteome