Increasing ceftriaxone resistance and multiple alterations of penicillin-binding proteins among penicillin-resistant Streptococcus pneumoniae isolates in Taiwan

Antimicrob Agents Chemother. 2007 Sep;51(9):3404-6. doi: 10.1128/AAC.01563-06. Epub 2007 Jun 25.

Abstract

The rate of nonsusceptibility of penicillin-resistant Streptococcus pneumoniae strains to ceftriaxone increased significantly in Taiwan in 2005. Approximately 90% of the ceftriaxone-nonsusceptible isolates were found to be of four major serotypes (serotypes 6B, 14, 19F, and 23F). Seven amino acid alterations in the penicillin-binding protein 2B transpeptidase-encoding region specifically contributed to the resistance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution
  • Aminoacyltransferases / metabolism
  • Anti-Bacterial Agents / pharmacology*
  • Ceftriaxone / pharmacology*
  • DNA Primers
  • Drug Resistance, Bacterial
  • Electrophoresis, Gel, Pulsed-Field
  • Humans
  • Penicillin Resistance / genetics*
  • Penicillin-Binding Proteins / genetics*
  • Penicillin-Binding Proteins / metabolism
  • Pneumococcal Infections / epidemiology
  • Pneumococcal Infections / microbiology*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Streptococcus pneumoniae / drug effects*
  • Streptococcus pneumoniae / genetics*
  • Taiwan / epidemiology

Substances

  • Anti-Bacterial Agents
  • DNA Primers
  • Penicillin-Binding Proteins
  • Ceftriaxone
  • Aminoacyltransferases
  • penicillin-binding protein 2b, Streptococcus