Abstract
The design, synthesis, and in vitro activity of a series of novel 5-ethynyl-2-aryloxybenzylamine-based histamine H(3) ligands that are also serotonin reuptake transporters is described.
MeSH terms
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Animals
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Antidepressive Agents / pharmacology
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Benzylamines / chemistry*
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Chemistry, Pharmaceutical / methods*
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Drug Design
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Histamine Antagonists / chemical synthesis*
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Histamine Antagonists / pharmacology*
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Humans
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Kinetics
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Models, Chemical
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Protein Binding
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Rats
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Receptors, Histamine H3 / chemistry*
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Selective Serotonin Reuptake Inhibitors / chemistry
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Selective Serotonin Reuptake Inhibitors / pharmacology*
Substances
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Antidepressive Agents
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Benzylamines
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Histamine Antagonists
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Receptors, Histamine H3
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Serotonin Uptake Inhibitors