Objective: To research and evaluate the clinical efficacy of Xian-zhong injection in treating primary knee OA.
Methods: By using Lequesne instituted ISOA and Kellgren-Lawrance instituted X-ray class standard, 127 non-operation primaary knee OA patients were divided into three grades (Light, Moderate, Severe). To adopt randomized single controlled trial, each grade was divided into two groups, respectively injected Xian-zhong injection or Sodium Hyaluronate injection. Every injection's volume was 2 ml and injected one per week, then consecutively injected one month. Finally we followed up in the first month, third month, sixth month, afterward we did every six months.
Results: After followed up one - twenty-four months we found ISOA score less than thirteen and K-LA X-ray class standard less than III grade, the clinical efficacy of two kind of injections was better. But ISOA score more than thirteen and K-LA X-ray class standard mord than III grade, the clinical efficacy was bad. The follow-up showed that the total effective rate and excellent rate between Xian-zhong injection group and Sodium Hyaluronate injection group weren't significantly different.
Conclusion: Xian-zhong injection can improve the clinical efficacy of primary knee OA, it has the greatest researching value and using furthermore.