MP4- and MOG:35-55-induced EAE in C57BL/6 mice differentially targets brain, spinal cord and cerebellum

J Neuroimmunol. 2007 Sep;189(1-2):31-40. doi: 10.1016/j.jneuroim.2007.06.016. Epub 2007 Jul 25.

Abstract

Mechanism-oriented studies of EAE rely mostly on gene-modified mice on the C57BL/6 background. Here we report that MP4-induced EAE displays characteristic differences in CNS pathology as compared to MOG peptide 35-55-elicited disease. While in the latter, the topology of CNS infiltration remained unchanged throughout the disease, in MP4-induced EAE it was dynamic and stage-dependent shifting from the brain to the spinal cord and finally to the cerebellum. Unlike in the MOG peptide model, the frequencies and sizes of CNS lesions in MP4-induced disease showed a clear correlation with clinical disease severity. These characteristic features of MP4-induced EAE may contribute to modelling the complex spectrum of disease manifestations seen in MS.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Central Nervous System / drug effects*
  • Central Nervous System / pathology
  • Disease Models, Animal
  • Drug Delivery Systems
  • Encephalomyelitis, Autoimmune, Experimental / chemically induced*
  • Encephalomyelitis, Autoimmune, Experimental / pathology*
  • Female
  • Glycoproteins / administration & dosage*
  • Mice
  • Mice, Inbred C57BL
  • Myelin Basic Protein / administration & dosage*
  • Myelin Proteolipid Protein / administration & dosage*
  • Myelin-Oligodendrocyte Glycoprotein
  • Peptide Fragments / administration & dosage*
  • Recombinant Fusion Proteins / administration & dosage*
  • Time Factors

Substances

  • Glycoproteins
  • MP4 protein, chimeric
  • Myelin Basic Protein
  • Myelin Proteolipid Protein
  • Myelin-Oligodendrocyte Glycoprotein
  • Peptide Fragments
  • Recombinant Fusion Proteins
  • myelin oligodendrocyte glycoprotein (35-55)