Abstract
Dipropofol has a strong antibacterial activity against Gram-positive bacteria. However, it lacked the solubility in water and this property was supposed to limit its efficacy. We tried to improve the solubility and found a new solubilization method of dipropofol in water by the addition of a monosaccharide or ascorbic acid.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkanes / chemistry*
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Alkanes / pharmacology
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Ascorbic Acid / chemistry
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Drug Synergism
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Escherichia coli / drug effects
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Excipients
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Microbial Sensitivity Tests
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Monosaccharides / chemistry*
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Oxidation-Reduction
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Phenols / chemistry*
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Phenols / pharmacology
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Solubility
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Staphylococcus aureus / drug effects
Substances
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Alkanes
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Anti-Bacterial Agents
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Excipients
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Monosaccharides
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Phenols
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dipropofol
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Ascorbic Acid