Abstract
AMP-activated protein kinase (AMPK) has emerged as a metabolic "fuel gauge," which oscillates between anabolic and catabolic processes that ultimately influence energy balance. A study in this issue of the JCI by Claret et al. now extends the role of AMPK in medial basal hypothalamic neurons (see the related article beginning on page 2325). These findings maintain AMPK signaling as a common cellular mechanism in proopiomelanocortin and neuropeptide Y/agouti-related protein neurons and links hypothalamic AMPK to coordinated energy and glucose homeostasis.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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AMP-Activated Protein Kinases
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Agouti-Related Protein
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Animals
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Eating / physiology
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Energy Metabolism / physiology*
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Glucose / metabolism
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Homeostasis / physiology*
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Hypothalamus / metabolism*
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Insulin / metabolism
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Intercellular Signaling Peptides and Proteins / deficiency
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Intercellular Signaling Peptides and Proteins / metabolism*
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Leptin / metabolism
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Mice
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Mice, Knockout
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Multienzyme Complexes / deficiency
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Multienzyme Complexes / metabolism*
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Neurons / metabolism*
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Pro-Opiomelanocortin / deficiency
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Pro-Opiomelanocortin / metabolism*
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Protein Serine-Threonine Kinases / deficiency
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Protein Serine-Threonine Kinases / metabolism*
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Signal Transduction / physiology
Substances
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Agouti-Related Protein
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Insulin
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Intercellular Signaling Peptides and Proteins
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Leptin
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Multienzyme Complexes
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Pro-Opiomelanocortin
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Protein Serine-Threonine Kinases
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AMP-Activated Protein Kinases
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Glucose