Facilitated hexose transporters: new perspectives on form and function

Andrei R Manolescu; Kate Witkowska; Adam Kinnaird; Tara Cessford; Chris Cheeseman

doi:10.1152/physiol.00011.2007

Facilitated hexose transporters: new perspectives on form and function

Physiology (Bethesda). 2007 Aug:22:234-40. doi: 10.1152/physiol.00011.2007.

Authors

Andrei R Manolescu¹, Kate Witkowska, Adam Kinnaird, Tara Cessford, Chris Cheeseman

Affiliation

¹ Membrane Protein Research Group, Department of Physiology, University of Alberta, Edmonton, Alberta, Canada.

PMID: 17699876
DOI: 10.1152/physiol.00011.2007

Abstract

The recent sequencing of the human genome has resulted in the addition of nine new hGLUT isoforms to the SLC2A family, many of which have widely varying substrate specificity, kinetic behavior, and tissue distribution. This review examines some new hypotheses related to the structure and function of these proteins.

Publication types

Review

MeSH terms

Amino Acid Sequence
Biological Transport / physiology
Cell Membrane Permeability / physiology
Glucose Transport Proteins, Facilitative / analysis
Glucose Transport Proteins, Facilitative / chemistry
Glucose Transport Proteins, Facilitative / metabolism*
Hexoses / metabolism*
Humans
Molecular Sequence Data
Protein Isoforms
Substrate Specificity / physiology

Substances

Glucose Transport Proteins, Facilitative
Hexoses
Protein Isoforms