Abstract
The single genomic locus, AbetaH-J-J, encodes three functionally distinct proteins aspartyl beta-hydroxylase, junctin and junctate by alternative splicing. Among these three proteins, junctin and junctate could play important roles in the regulation of intracellular Ca(2+) by regulating either Ca(2+) release from intracellular Ca(2+) stores or Ca(2+) influx in various biological processes. Here we review recent findings concerning the expressional regulations and the proposed functions of junctin and junctate.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Calcium / metabolism
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Calcium-Binding Proteins / physiology*
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Calsequestrin / chemistry
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Carrier Proteins / chemistry
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Gene Expression Regulation*
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Humans
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Membrane Proteins / physiology*
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Mice
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Mice, Knockout
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Mice, Transgenic
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Mixed Function Oxygenases / chemistry
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Mixed Function Oxygenases / physiology*
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Muscle Proteins / chemistry
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Muscle Proteins / physiology*
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Protein Isoforms
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Ryanodine Receptor Calcium Release Channel / metabolism
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Signal Transduction
Substances
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Calcium-Binding Proteins
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Calsequestrin
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Carrier Proteins
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Membrane Proteins
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Muscle Proteins
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Protein Isoforms
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Ryanodine Receptor Calcium Release Channel
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triadin
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Asph protein, mouse
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Mixed Function Oxygenases
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aspartic acid 2-oxoglutarate-dependent dioxygenase
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Calcium