Vaccine containing natural TLR ligands protects from Salmonella typhimurium infection in mice and acute respiratory infections in children

Adv Exp Med Biol. 2007:601:377-80. doi: 10.1007/978-0-387-72005-0_40.

Abstract

It has been shown that a single parenteral administration of vaccine containing bacterial ligands for TLRI, TLR2, TLR4, TLR6, and TLR9 in mice induced rapid (24 h after administration) and effective (100%), but short-term (96 h) protection against lethal challenge with Salmonella typhimurium. Repeated mucosal applications of this vaccine stimulated long-term (up to 9 months) protection against acute respiratory infections in children of preschool age.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Animals
  • Child
  • Humans
  • Immune System
  • Immunity, Innate
  • Ligands
  • Mice
  • Mice, Inbred CBA
  • Mucous Membrane / immunology
  • Mucous Membrane / metabolism
  • Respiratory Tract Infections / diagnosis
  • Respiratory Tract Infections / immunology*
  • Salmonella Infections / immunology*
  • Salmonella typhimurium / metabolism*
  • Toll-Like Receptors / chemistry*
  • Toll-Like Receptors / immunology*

Substances

  • Ligands
  • Toll-Like Receptors