Case of corneal melting associated with the use of topical nepafenac

Cornea. 2007 Sep;26(8):1002-3. doi: 10.1097/ICO.0b013e3180cfe626.

Abstract

Purpose: To report a case of corneal melting associated with the use of the topical nonsteroidal anti-inflammatory agent Nepafenac.

Methods: Case report and literature review.

Results: A 62-year-old woman with a complicated ocular history developed corneal melting associated with the use of Nepafenac. On discontinuation of Nepafenac, the melt rapidly resolved.

Conclusions: Topical nonsteroidal anti-inflammatory agents have been associated with corneal ulceration and stromal melts. This is, to our knowledge, the first reported case involving the new agent, Nepafenac.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Benzeneacetamides / adverse effects*
  • Cornea / drug effects*
  • Corneal Ulcer / chemically induced*
  • Corneal Ulcer / diagnosis
  • Decompression, Surgical
  • Female
  • Humans
  • Middle Aged
  • Pain / drug therapy
  • Phenylacetates / adverse effects*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Benzeneacetamides
  • Phenylacetates
  • nepafenac