Abstract
The small ubiquitin-like modifier (SUMO) is involved in many cellular processes and is required for normal growth and development in all eukaryotes. Whereas lower eukaryotes have a single version of SUMO, higher eukaryotes have three versions: SUMO-1, -2 and -3. Similarly to most other ubiquitin-like proteins, the primary translation products of the SUMO genes need to be proteolytically processed to expose the C-terminal glycine that will be linked to lysine side chains in substrates. Processing of SUMO precursors is mediated by SUMO-specific proteases that also remove SUMO from modified proteins and depolymerise poly-SUMO chains.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Cysteine Endopeptidases / classification
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Cysteine Endopeptidases / genetics
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Cysteine Endopeptidases / metabolism
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Endopeptidases / chemistry
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Endopeptidases / classification
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Endopeptidases / genetics
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Endopeptidases / metabolism*
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Gene Expression Regulation
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Humans / classification
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Humans / genetics
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Models, Molecular
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Phylogeny
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Protein Conformation
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Protein Isoforms / metabolism
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Protein Processing, Post-Translational
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Saccharomyces cerevisiae Proteins / metabolism
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Small Ubiquitin-Related Modifier Proteins / metabolism*
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Ubiquitin / metabolism
Substances
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Protein Isoforms
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Saccharomyces cerevisiae Proteins
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Small Ubiquitin-Related Modifier Proteins
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Ubiquitin
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Endopeptidases
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ULP2 protein, S cerevisiae
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Cysteine Endopeptidases
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Ulp1 protease