Abstract
We describe a synthesis of ketones 3 (X = O-R or CN; Y = H or alkyl), which are useful building blocks for the preparation of analogs of the potent antifungal agent sordarin, 1. Congeners of 1 constructed from 3 should permit detailed SAR investigations of the terpenoid core of the natural product.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology
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Indenes / chemical synthesis*
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Indenes / chemistry
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Indenes / pharmacology
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Molecular Structure
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Structure-Activity Relationship
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Terpenes / chemical synthesis
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Terpenes / chemistry*
Substances
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Antifungal Agents
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Indenes
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Terpenes
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sordarin