Dried blood spots versus sera for detection of rubella virus-specific immunoglobulin M (IgM) and IgG in samples collected during a rubella outbreak in Peru

Clin Vaccine Immunol. 2007 Nov;14(11):1522-5. doi: 10.1128/CVI.00144-07. Epub 2007 Sep 19.

Abstract

Most persons with rubella virus-specific immunoglobulin M (IgM)- or IgG-positive sera tested positive (98% [n = 178] and 99% [n = 221], respectively) using paired filter paper dried blood spot (DBS) samples, provided that DBS indeterminate results were called positive. For persons with IgM- or IgG-negative sera, 97% and 98%, respectively, were negative using DBS.

Publication types

  • Comparative Study

MeSH terms

  • Antibodies, Viral / blood*
  • Antibodies, Viral / immunology
  • Blood Specimen Collection
  • Disease Outbreaks
  • Humans
  • Immunoglobulin G / blood*
  • Immunoglobulin G / immunology
  • Immunoglobulin M / blood*
  • Immunoglobulin M / immunology
  • Peru / epidemiology
  • Rubella / diagnosis*
  • Rubella / epidemiology
  • Rubella / immunology
  • Rubella / virology
  • Rubella virus / immunology*
  • Sensitivity and Specificity
  • Serologic Tests

Substances

  • Antibodies, Viral
  • Immunoglobulin G
  • Immunoglobulin M
  • rubella antibodies