Acute-myeloid-leukemia-targeted toxins kill tumor cells by cell-type-specific mechanisms and synergize with TRAIL to allow manipulation of the extent and mechanism of tumor cell death

MeSH terms

• Acute Disease
• Amino Acid Chloromethyl Ketones / pharmacology
• Antineoplastic Agents / pharmacology*
• Antineoplastic Agents / toxicity
• Apoptosis / drug effects
• Benzamides / antagonists & inhibitors
• Caspases / physiology
• Cell Death / drug effects
• Cell Line, Tumor / drug effects
• Diphtheria Toxin / pharmacology*
• Diphtheria Toxin / toxicity
• Drug Delivery Systems
• Drug Resistance, Neoplasm
• Drug Screening Assays, Antitumor
• Drug Synergism
• Enzyme Activation / drug effects
• Humans
• Interleukin-3 / pharmacology*
• Interleukin-3 / toxicity
• Leukemia, Myeloid / drug therapy*
• Leukemia, Myeloid / pathology
• Neoplasm Proteins / drug effects
• Neoplasm Proteins / physiology
• Pyridines / antagonists & inhibitors
• Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / drug effects
• Receptors, Interleukin-3 / drug effects
• Recombinant Fusion Proteins / pharmacology*
• Recombinant Fusion Proteins / toxicity
• TNF-Related Apoptosis-Inducing Ligand / pharmacology
• U937 Cells / drug effects