Can probability of genetic mutation be an indicator of clinical relevance?

Genomics. 2007 Dec;90(6):746-50. doi: 10.1016/j.ygeno.2007.07.006. Epub 2007 Oct 24.

Abstract

NPM1 gene mutation evaluated on a population basis is a valuable and realistic tool to reflect the pathophysiological relevance of cancer. In a comparison of the NPM1 cDNA of human bladder cancer with its consensus sequence, we have found that a higher NPM1 sequence identity in a population is consistent with poor tumor differentiation, advanced tumor stage, and likelihood of recurrence. These data imply that "probability" of NPM1 mutation is an indicator of status of malignancy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Base Sequence
  • Carcinoma, Transitional Cell / genetics
  • Carcinoma, Transitional Cell / pathology
  • DNA Primers / genetics
  • DNA, Complementary / genetics
  • DNA, Neoplasm / genetics
  • Female
  • Genetics, Population
  • Humans
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Mutation*
  • Neoplasm Staging
  • Nuclear Proteins / genetics*
  • Nucleophosmin
  • Probability
  • Recurrence
  • Sequence Homology, Nucleic Acid
  • Urinary Bladder Neoplasms / genetics*
  • Urinary Bladder Neoplasms / pathology

Substances

  • DNA Primers
  • DNA, Complementary
  • DNA, Neoplasm
  • NPM1 protein, human
  • Nuclear Proteins
  • Nucleophosmin

Associated data

  • RefSeq/NM_002520