The application of texture analysis to medical images may require the calculation of texture descriptors on regions of interest (ROIs) that are not completely filled by the tissue under analysis. If a texture descriptor is calculated using such "deficient" ROIs, the accuracy and computational speed may be adversely affected. This study applied 198 texture descriptors from five texture classes (first-order statistical, second-order statistical, Fourier, fractal, and Laws' filtered) to lung parenchyma ROIs automatically extracted from the thoracic CT scans of ten patients. Statistically significant differences in the values of 138 of these texture descriptors were demonstrated when calculated on deficient ROIs. Three extrapolation methods (mean fill, tiled fill, and CLEAN deconvolution) then were applied to correct the deficient ROIs. Texture descriptor values were calculated and compared for the original, deficient, and corrected ROIs (based on the three extrapolation methods). Each extrapolation method induced statistically significant improvements in texture descriptor accuracy for some subset of texture descriptors. CLEAN deconvolution improved the greatest number of descriptors, demonstrated the best overall accuracy, and created ROIs that were visually most similar to the original ROIs.