Descending necrotizing mediastinitis (DNM) is a fatal disease that is caused by a cervical or odontogenical infection spreading downward to the mediastinum through anatomical cervical spaces. The mortality rate of DNM is still high. We have experience of 2 cases of DNM. In case 1 patient, a cervical abscess expanded to the esophageal hiatus through the superior and posterior mediastinum. A right minithoracotomy on the triangle of auscultation was performed with a thoracoscope in order to dissect the necrotic materials and drain the abscess. In case 2 patient, a left second costal cartilage resection was performed to approach the anterior mediastinal abscess. Both patients recovered well.