Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina

Antimicrob Agents Chemother. 2007 Dec;51(12):4466-70. doi: 10.1128/AAC.00726-07. Epub 2007 Oct 15.

Abstract

Transferable quinolone resistance has not previously been reported in Argentina. Here we describe three complex class 1 integrons harboring the novel allele qnrB10 in a unique region downstream of orf513, one of them also containing aac(6')-Ib-cr within the variable region of integrons. The three arrays differed from bla(CTX-M-2)-bearing integrons, which are broadly distributed in Argentina.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Argentina
  • Bacterial Proteins / genetics
  • Base Sequence
  • Cross Infection / microbiology
  • DNA Transposable Elements / genetics*
  • Drug Resistance, Bacterial / genetics*
  • Enterobacteriaceae / drug effects
  • Enterobacteriaceae / enzymology
  • Enterobacteriaceae / genetics*
  • Enterobacteriaceae Infections / microbiology
  • Humans
  • Integrons / genetics*
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Sequence Analysis, DNA
  • Sequence Homology, Nucleic Acid
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism

Substances

  • Bacterial Proteins
  • DNA Transposable Elements
  • beta-Lactamases

Associated data

  • GENBANK/DQ631414
  • GENBANK/EF636461
  • GENBANK/EU052800
  • GENBANK/EU091084