The development of interfaces linking the human nervous system with artificial devices is an important area of research and several groups are now addressing it. Interfaces represent the key enabling technology for the development of devices usable for the restoration of motor and sensory function in subjects affected by neurological disorders, injuries or amputations. For example, current hand prostheses use electromyographic (EMG) signals to extract volitional commands but this limits the possibility of controlling several degrees of freedom and of delivering sensory feedback. To achieve these goals, implantable neural interfaces are required. Among the candidate interfaces with the peripheral nervous system intra-neural electrodes seem to be an interesting solution due to their bandwidth and ability to access volition and deliver sensory feedback. However, several drawbacks have to be addressed in order to increase their usability. In this paper, experiments to address many of these issues are presented as part of the development of a new generation of intra-neural electrodes. The results showed seem to confirm that these new interfaces seem to have interesting properties and that they can represent a significant improvement of the state of the art. Extensive experiments will be carried out in the future to validate these results.