[Scale-up of the fermentation of Leptospira interrogans canicola canicola for the production of vax-SPIRAL vaccine]

José Daniel Benítez Zamora; Kenia Fernández Enrique; Raúl Gutiérrez Boué; Florinda Hernández Torres; Janet Lazo Airado; Damián Rojo Hernández

[Scale-up of the fermentation of Leptospira interrogans canicola canicola for the production of vax-SPIRAL vaccine]

Rev Cubana Med Trop. 2005 Jan-Apr;57(1):71-2.

[Article in Spanish]

Authors

José Daniel Benítez Zamora¹, Kenia Fernández Enrique, Raúl Gutiérrez Boué, Florinda Hernández Torres, Janet Lazo Airado, Damián Rojo Hernández

Affiliation

¹ Instituto Finlay, Ciudad de La Habana, Cuba.

PMID: 17966489

Abstract

The operational conditions for the production of vaccine vax-SPIRAL were established at the scale of 100 L. It was concluded that it should be carried out with an air flow of 10 L/min (0.1 vvm) and without mechanical agitation.

Publication types

English Abstract

MeSH terms

Bacterial Vaccines* / economics
Bacterial Vaccines* / standards
Bacteriological Techniques
Fermentation*
Humans
Leptospira interrogans serovar canicola / immunology*
Leptospira interrogans serovar canicola / metabolism*
Leptospirosis / prevention & control*
Time Factors

Substances

Bacterial Vaccines