T helper 17 cells get the NOD

Daniel B Stetson; Ruslan Medzhitov

doi:10.1016/j.immuni.2007.10.005

T helper 17 cells get the NOD

Immunity. 2007 Oct;27(4):546-8. doi: 10.1016/j.immuni.2007.10.005.

Authors

Daniel B Stetson¹, Ruslan Medzhitov

Affiliation

¹ Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. daniel.stetson@yale.edu

PMID: 17967409
DOI: 10.1016/j.immuni.2007.10.005

Abstract

Interleukin-17 (IL-17)-producing helper T cells play a role in pathogen defense and autoimmunity. In this issue of Immunity, van Beelen et al. (2007) reveal a pathway that elicits potent IL-17 production from memory T cells through activation of the intracellular receptor NOD2.

Publication types

Comment
Review

MeSH terms

Animals
Humans
Immunologic Memory
Interleukin-17 / biosynthesis*
Interleukin-17 / immunology
Nod2 Signaling Adaptor Protein / metabolism*
T-Lymphocyte Subsets / immunology*
T-Lymphocyte Subsets / metabolism
T-Lymphocytes, Helper-Inducer / immunology*
T-Lymphocytes, Helper-Inducer / metabolism

Substances

Interleukin-17
NOD2 protein, human
Nod2 Signaling Adaptor Protein