Abstract
A series of benzimidazole- and benzothiazole-quinones has been synthesized. The ability of these heterocyclic quinones to act as substrates for recombinant human NAD(P)H:quinone oxidoreductase (NQO1), a two-electron reductase upregulated in tumour cells, was determined. Overall, the quinones were excellent substrates for NQO1.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzimidazoles / chemical synthesis
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Benzimidazoles / chemistry
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Benzimidazoles / metabolism*
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Benzothiazoles / chemical synthesis
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Benzothiazoles / chemistry
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Benzothiazoles / metabolism*
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Humans
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Kinetics
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NAD(P)H Dehydrogenase (Quinone) / metabolism*
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Quinones / chemical synthesis
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Quinones / chemistry
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Quinones / metabolism*
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Recombinant Proteins / metabolism
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Substrate Specificity
Substances
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Benzimidazoles
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Benzothiazoles
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Quinones
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Recombinant Proteins
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benzimidazole
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NAD(P)H Dehydrogenase (Quinone)
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NQO1 protein, human
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benzothiazole