Pigment epithelium-derived factor (PEDF) prevents advanced glycation end products (AGEs)-elicited endothelial nitric oxide synthase (eNOS) reduction through its anti-oxidative properties

Protein Pept Lett. 2007;14(8):832-5. doi: 10.2174/092986607781483705.

Abstract

PEDF is an effective inhibitor of angiogenesis in the eye with neuronal differentiating activity. Here, we show that PEDF prevents the AGEs-elicited eNOS reduction through its anti-oxidative properties. Our present study suggests that PEDF may also play a protective role against atherosclerosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Endothelium, Vascular / enzymology
  • Eye Proteins / pharmacology*
  • Gene Expression / drug effects
  • Glycation End Products, Advanced / antagonists & inhibitors*
  • Humans
  • Nerve Growth Factors / pharmacology*
  • Nitric Oxide Synthase Type III / metabolism*
  • Reactive Oxygen Species / antagonists & inhibitors*
  • Serpins / pharmacology*

Substances

  • Eye Proteins
  • Glycation End Products, Advanced
  • Nerve Growth Factors
  • Reactive Oxygen Species
  • Serpins
  • pigment epithelium-derived factor
  • NOS3 protein, human
  • Nitric Oxide Synthase Type III