Abstract
The mechanisms leading to CNS disorders after EBV infections are unclear. We report the case of a patient who developed a severe, but reversible, encephalopathy following an infectious mononucleosis. We detected no EBV DNA in the blood or in the cerebrospinal fluid (CSF) and no EBV-specific antibodies in the CSF. However, we found a potent MOG-specific cellular and humoral immune response. Interestingly, MOG-specific cellular immune response rapidly decreased, paralleling the improvement of clinical condition. In conclusion, this detailed study shows that acute EBV infection can trigger a potent auto-inflammatory response in the CNS, without evidence of an overt infection.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antibodies / metabolism*
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Brain Diseases / blood
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Brain Diseases / cerebrospinal fluid
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Brain Diseases / immunology*
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Brain Diseases / pathology
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Cell Proliferation
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Disease Progression
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Enzyme-Linked Immunosorbent Assay / methods
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Epstein-Barr Virus Infections / blood
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Epstein-Barr Virus Infections / cerebrospinal fluid
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Epstein-Barr Virus Infections / immunology*
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Epstein-Barr Virus Infections / pathology
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Herpesvirus 4, Human / metabolism
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Humans
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Interferon-gamma / metabolism
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Male
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Myelin Basic Protein / metabolism
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Myelin Proteins
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Myelin-Associated Glycoprotein / immunology*
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Myelin-Oligodendrocyte Glycoprotein
Substances
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Antibodies
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MOG protein, human
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Myelin Basic Protein
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Myelin Proteins
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Myelin-Associated Glycoprotein
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Myelin-Oligodendrocyte Glycoprotein
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Interferon-gamma