Inhibition of human immunodeficiency virus type I replication by derivatives of gossypol

Pharmacol Res. 1991 Dec;24(4):407-12. doi: 10.1016/1043-6618(91)90045-y.

Abstract

Gossypol (I) and its derivatives gossylic nitrile-1,1'-diacetate (II), gossylic iminolactone (III) and gossylic lactone (IV) inhibit the replication of human immunodeficiency virus type 1 in vitro in the order III greater than I greater than II,IV, indicating that derivatives of gossypol can retain antiviral activities. All of the derivatives are less cytotoxic than gossypol.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antiviral Agents / pharmacology
  • Cell Line
  • Cell Survival / drug effects
  • Gossypol / analogs & derivatives*
  • Gossypol / pharmacology
  • Gossypol / toxicity
  • HIV-1 / drug effects*
  • Humans
  • Virus Replication / drug effects

Substances

  • Antiviral Agents
  • gossylic lactone
  • gossylic iminolactone
  • gossylic nitrile-1,1'-diacetate
  • Gossypol