Thermodynamic studies on PNA and PNA/DNA dendrimer formation

Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):1173-6. doi: 10.1080/15257770701527703.

Abstract

In this work we report a kinetic and thermodynamic study relative to the formation of gel systems based on PNA and PNA/DNA dendrimers, useful for drug delivery or diagnostic applications. We realized two kinds of systems: a PNA-based monomolecular system formed by an autoassembling PNA tridendron (A) and a PNA/DNA bimolecular system based on a PNA tridendron with a mixed sequence and a DNA crosslinker (B). Both systems have the ability to form a three-dimensional network by means of specific W-C base pairing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Pairing
  • Base Sequence
  • Cross-Linking Reagents
  • DNA / chemical synthesis
  • DNA / chemistry*
  • DNA / radiation effects
  • Dendrimers / chemical synthesis
  • Dendrimers / chemistry*
  • Dendrimers / radiation effects
  • Gels
  • Kinetics
  • Molecular Conformation / radiation effects
  • Oligodeoxyribonucleotides / chemical synthesis
  • Oligodeoxyribonucleotides / chemistry
  • Oligodeoxyribonucleotides / radiation effects
  • Peptide Nucleic Acids / chemical synthesis
  • Peptide Nucleic Acids / chemistry*
  • Peptide Nucleic Acids / radiation effects
  • Photochemistry
  • Thermodynamics
  • Ultraviolet Rays

Substances

  • Cross-Linking Reagents
  • Dendrimers
  • Gels
  • Oligodeoxyribonucleotides
  • Peptide Nucleic Acids
  • DNA