Porphyrin-DNA: a supramolecular scaffold for functional molecules on the nanometre scale

Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1533-8. doi: 10.1080/15257770701544468.

Abstract

We are pursuing the aim to use DNA as a supramolecular scaffold for the creation of electronically functional molecules on the nanometre scale. Here, we give a review on our results on porphyrin modified nucleotides used for this purpose. A general synthetic route to porphyrin-nucleotides has been devised, and the building blocks can be incorporated into oligonucleotides using standard solid phase synthesis methods. Up to 11 porphyrins were incorporated into DNA, reaching a length of approximately 4 nm in the array. The spectroscopic data are consistent with a porphyrin induced secondary structure stabilisation in the single strands.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA / chemistry*
  • Nanostructures / chemistry*
  • Nucleotides / chemistry*
  • Porphyrins / chemistry*

Substances

  • Nucleotides
  • Porphyrins
  • DNA