Abstract
A series of omega-dialkylaminoalkyl esters of 3-dialkylamino-4,7,7-trimethyl-N-phenylbicyclo[2.2.1]hept-2-ene-2- iminothiolic acids 3 was prepared by reaction of 4,7,7-trimethyl-3-(dimethylamino or 1-piperidinyl)-N-phenylbicyclo[2.2.1] hept-2-ene-2-thiocarboxamides with a number of omega-chloroalkyldialkylamines in the presence of sodium hydride in DMF or benzene solution. Some esters 3 showed an appreciable local anesthetic activity in mice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anesthetics, Local / chemical synthesis*
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Anesthetics, Local / pharmacology
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Animals
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Anti-Arrhythmia Agents / pharmacology
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Blood Pressure / drug effects
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Bridged Bicyclo Compounds / chemical synthesis*
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Bridged Bicyclo Compounds / pharmacology
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Magnetic Resonance Spectroscopy
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Mice
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Pain Measurement
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Rats
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Spectrophotometry, Infrared
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Thiocyanates / chemical synthesis*
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Thiocyanates / pharmacology
Substances
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Anesthetics, Local
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Anti-Arrhythmia Agents
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Bridged Bicyclo Compounds
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Thiocyanates