Abstract
The purpose of the present study was to investigate the impact of post-traumatic stress disorder (PTSD) symptoms on hypothalamic-pituitary-adrenal axis feedback regulation in 18 female patients with borderline personality disorder (BPD) and 21 healthy controls. Reduced feedback sensitivity was found in BPD patients with a low number of PTSD symptoms, while findings in the BPD group with a high number of PTSD symptoms did not differ from those in controls. The results suggest a hypo-suppression in the dexamethasone suppression test in BPD with few PTSD symptoms.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Borderline Personality Disorder / blood
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Borderline Personality Disorder / physiopathology*
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Borderline Personality Disorder / psychology*
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Child
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Child Abuse / psychology
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Child Abuse, Sexual / psychology
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Dexamethasone*
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Feedback, Physiological
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Female
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Humans
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Hydrocortisone / metabolism
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Hypothalamo-Hypophyseal System / drug effects
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Hypothalamo-Hypophyseal System / physiopathology
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Pituitary-Adrenal System / drug effects
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Pituitary-Adrenal System / physiopathology
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Psychiatric Status Rating Scales
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Stress Disorders, Post-Traumatic / blood
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Stress Disorders, Post-Traumatic / physiopathology*
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Stress Disorders, Post-Traumatic / psychology*
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Surveys and Questionnaires
Substances
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Dexamethasone
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Hydrocortisone