Synthesis and cytotoxicity of a cobaltcarbonyl-alkyne enkephalin bioconjugate

Chem Commun (Camb). 2008 Jan 14:(2):232-4. doi: 10.1039/b712886j. Epub 2007 Oct 22.

Abstract

A solid-phase synthesized propargyl derivative of the neuropeptide leucine-enkephalin (Enk) reacts rapidly and quantitatively with Co(2)(CO)(8) to give the Co(2)(CO)(6)-alkyne labeled peptide , which is the first organometallic peptide bioconjugate to show significant toxicity against two different tumor cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Carbonic Acid / chemistry*
  • Cell Survival / drug effects
  • Cobalt / chemistry*
  • Enkephalins / chemical synthesis*
  • Enkephalins / chemistry
  • Enkephalins / toxicity*
  • HeLa Cells
  • Humans
  • Molecular Structure
  • Spectrophotometry, Infrared

Substances

  • Alkynes
  • Enkephalins
  • Cobalt
  • Carbonic Acid