Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema

J Invest Dermatol. 2008 Jun;128(6):1591-4. doi: 10.1038/sj.jid.5701206. Epub 2007 Dec 20.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • DNA Mutational Analysis
  • Dermatitis, Atopic / genetics*
  • Filaggrin Proteins
  • Gene Expression Regulation
  • Genetic Predisposition to Disease*
  • Genotype
  • Haplotypes
  • Humans
  • Intermediate Filament Proteins / genetics*
  • Models, Statistical
  • Mutation*
  • Odds Ratio
  • Phenotype

Substances

  • FLG protein, human
  • Filaggrin Proteins
  • Intermediate Filament Proteins