Gene expression profiling for improved dissection of acute leukemia: a recently identified immature myeloid/T-lymphoid subgroup as an example

Blood Cells Mol Dis. 2008 May-Jun;40(3):395-400. doi: 10.1016/j.bcmd.2007.10.006. Epub 2007 Dec 21.

Abstract

In this concise overview, we discuss recent findings concerning a distinct subgroup of acute myeloid/T-lymphoid leukemia. We describe how we identified these leukemias in multiple cohorts of acute myeloid leukemia (AML) using a combination of gene expression profiling and additional analytic approaches, and how we obtained insight in possible mechanisms leading to their phenotype.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • CCAAT-Enhancer-Binding Proteins / genetics*
  • CCAAT-Enhancer-Binding Proteins / metabolism
  • Gene Expression Profiling
  • Gene Expression Regulation, Leukemic*
  • Gene Silencing
  • Humans
  • Leukemia, Myeloid, Acute / genetics*
  • Leukemia, Myeloid, Acute / metabolism*
  • Leukemia, T-Cell / genetics*
  • Leukemia, T-Cell / metabolism*
  • Mutation
  • Receptor, Notch1 / genetics
  • Receptor, Notch1 / metabolism

Substances

  • CCAAT-Enhancer-Binding Proteins
  • CEBPA protein, human
  • NOTCH1 protein, human
  • Receptor, Notch1