Modulation of apoptosis to reverse chemoresistance

Methods Mol Biol. 2008:414:1-12. doi: 10.1007/978-1-59745-339-4_1.

Abstract

Interference with the innate apoptotic activity is a hallmark of neoplastic transformation and tumor formation. Modulation of the apoptotic cascade has been proposed as a new approach for the treatment of cancer. In this chapter, we discuss the role of apoptosis in ovarian cancer and the use of phenoxodiol as a model for the regulation of apoptosis and potential use as chemosensitizer for chemoresistant ovarian cancer cells.

Publication types

  • Evaluation Study
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Apoptosis / drug effects
  • Apoptosis / genetics*
  • Apoptosis / physiology*
  • Chemotherapy, Adjuvant
  • Drug Resistance, Neoplasm* / drug effects
  • Drug Resistance, Neoplasm* / genetics
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Inhibitor of Apoptosis Proteins / physiology
  • Isoflavones / pharmacology
  • Isoflavones / therapeutic use
  • Models, Biological
  • Neoplasms / drug therapy
  • X-Linked Inhibitor of Apoptosis Protein / genetics

Substances

  • Antineoplastic Agents
  • Inhibitor of Apoptosis Proteins
  • Isoflavones
  • X-Linked Inhibitor of Apoptosis Protein
  • phenoxodiol