In vitro enhancement by CpG ODN of phagocytic activity of rainbow trout head kidney phagocytes against fish pathogen Vibrio ordalii, but not against polystyrene particles

J Vet Med Sci. 2007 Dec;69(12):1287-90. doi: 10.1292/jvms.69.1287.

Abstract

Rainbow trout (Oncorhynchus mykiss) head kidney phagocytes precultured with a synthetic cytidine-phosphate-guanosine (CpG) oligodeoxynucleotide (ODN) displayed significantly higher phagocytic activity against Vibrio ordalii than phagocytes precultured with non-CpG ODN. However, head kidney phagocytes precultured with CpG ODN did not show enhanced phagocytic activity against polystyrene particles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Fish Diseases / microbiology
  • Kidney / cytology
  • Oligodeoxyribonucleotides / pharmacology*
  • Oncorhynchus mykiss*
  • Phagocytes / drug effects*
  • Phagocytosis / drug effects*
  • Polystyrenes*
  • Vibrio*

Substances

  • Anti-Bacterial Agents
  • CPG-oligonucleotide
  • Oligodeoxyribonucleotides
  • Polystyrenes