Use of log-skew-normal distribution in analysis of continuous data with a discrete component at zero

Stat Med. 2008 Aug 15;27(18):3643-55. doi: 10.1002/sim.3210.

Abstract

The problem of analyzing a continuous variable with a discrete component is addressed within the framework of the mixture model proposed by Moulton and Halsey (Biometrics 1995; 51:1570-1578). The model can be generalized by the introduction of the log-skew-normal distribution for the continuous component, and the fit can be significantly improved by its use, while retaining the interpretation of regression parameter estimates. Simulation studies and application to a real data set are used for demonstration.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Biomedical Research / statistics & numerical data
  • Calcification, Physiologic
  • Coronary Artery Disease
  • Data Interpretation, Statistical*
  • Humans
  • Models, Statistical*
  • Monte Carlo Method
  • Statistical Distributions*