Hypoxia, PAF, and necrotizing enterocolitis

Lipids. 1991 Dec;26(12):1340-3. doi: 10.1007/BF02536562.

Abstract

Necrotizing enterocolitis (NEC) is an important neonatal disease with a high mortality rate. The pathophysiology is unclear but epidemiologic studies suggest that hypoxia and infection are important risk factors. In this review we discuss the effect of hypoxia and platelet-activating factor (PAF) on intestinal blood flow and intestinal necrosis, and implicate PAF as an important mediator in hypoxia-induced intestinal injury. Finally we provide evidence that PAF may be important in neonatal NEC.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Azepines / therapeutic use
  • Enterocolitis / pathology
  • Enterocolitis / physiopathology*
  • Humans
  • Hypoxia / physiopathology*
  • Intestines / drug effects
  • Intestines / pathology
  • Intestines / physiology
  • Necrosis
  • Platelet Activating Factor / antagonists & inhibitors
  • Platelet Activating Factor / physiology*
  • Quinolinium Compounds / therapeutic use
  • Triazoles / therapeutic use

Substances

  • Azepines
  • Platelet Activating Factor
  • Quinolinium Compounds
  • Triazoles
  • SRI 63-441
  • WEB 2086