Abstract
We determine phenotypic susceptibility of human immunodeficiency virus type 2 (HIV-2) isolates to amprenavir, atazanavir, darunavir, indinavir, lopinavir, nelfinavir, saquinavir, and tipranavir. Saquinavir, lopinavir, and darunavir are potent against wild-type HIV-2 isolates and should be preferred as first-line options for HIV-2-infected patients. Other protease inhibitors are less active against HIV-2 than against HIV-1.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Darunavir
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HIV Protease / drug effects
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HIV Protease Inhibitors / pharmacology*
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HIV-2 / classification*
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HIV-2 / drug effects*
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HIV-2 / enzymology
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Humans
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Inhibitory Concentration 50
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Lopinavir
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Microbial Sensitivity Tests
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Phenotype
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Pyrimidinones / pharmacology
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Saquinavir / pharmacology
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Sulfonamides / pharmacology
Substances
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HIV Protease Inhibitors
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Pyrimidinones
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Sulfonamides
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Lopinavir
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HIV Protease
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Saquinavir
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Darunavir