[Genomic approaches to bone and joint diseases. Current status of human disease genomics in rheumatoid arthritis]

Abstract

Rheumatoid arthritis (RA) is an autoimmune/inflammatory disorder which causes progression of polyarticular destruction. RA is a multifactorial disorder, in which genetic and environmental factors contribute to the onset of diseases. Linkage analyses and case-control association studies in RA have identified several susceptible genes including genetic variation in human leukocyte antigen region. Here, we review major genes susceptible to RA, and discuss effects of these genes on production of anti-cyclic citrullinated peptides antibody.