Intramolecular acid-base catalysis of a phosphate diester: modeling the ribonuclease mechanism

J Am Chem Soc. 2008 Feb 27;130(8):2436-7. doi: 10.1021/ja710693x. Epub 2008 Feb 5.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acids / chemistry*
  • Binding Sites
  • Catalysis
  • Hydrogen Bonding
  • Hydrogen-Ion Concentration
  • Hydrolysis
  • Imidazoles / chemistry*
  • Kinetics
  • Models, Biological*
  • Models, Molecular
  • Molecular Structure
  • Organophosphates / chemistry*
  • Organophosphorus Compounds
  • Phosphates / chemistry*
  • Ribonuclease, Pancreatic / chemistry*
  • Spectrometry, Mass, Electrospray Ionization / methods
  • Stereoisomerism
  • Tandem Mass Spectrometry / methods

Substances

  • Acids
  • Imidazoles
  • Organophosphates
  • Organophosphorus Compounds
  • Phosphates
  • bis(2-(1-methyl-1H-imidazolyl)phenyl)phosphate
  • Ribonuclease, Pancreatic