HIV infection and tooth loss

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Mar;105(3):321-6. doi: 10.1016/j.tripleo.2007.10.012.

Abstract

Objectives: The objective of this study was to determine the relationship between HIV infection and tooth loss. Based on periodontal reports, we hypothesize HIV+ patients experience greater tooth loss than systemically healthy patients.

Study design: This was a retrospective cross-sectional chart study involving 193 HIV+ patients and 192 controls matched on age, race, gender, and smoking status. The relationships between tooth loss and age, race, gender, smoking, CD4+ cell count, and viral load were determined. This study used a 2-year follow-up/maintenance period and was conducted during the era of highly active antiretroviral therapy (HAART).

Results: Tooth loss between groups was not significantly different at any time point: (1) before dental treatment; (2) after initial periodontal and restorative treatment; and (3) following a 2-year maintenance period. Age, race, and smoking were risk factors for tooth loss. Among HIV+ individuals, CD4+ cell count and viral load did not influence tooth loss.

Conclusions: HIV infection, in the era of HAART, does not appear to be a risk factor for tooth loss. We also did not find any association between tooth loss and indices of HIV disease progression.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Analysis of Variance
  • Antiretroviral Therapy, Highly Active / adverse effects
  • CD4 Lymphocyte Count
  • Case-Control Studies
  • Cross-Sectional Studies
  • Dental Care for Chronically Ill*
  • Female
  • HIV Infections / complications*
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Risk Factors
  • Smoking
  • Tooth Loss / etiology*
  • Xerostomia / chemically induced