[Two advanced/recurrent breast cancer cases effectively treated by trastuzumab/capecitabine combination therapy]

Gan To Kagaku Ryoho. 2008 Feb;35(2):319-22.
[Article in Japanese]

Abstract

Trastuzumab/capecitabine combination therapy was performed for two advanced/recurrent breast cancer cases with acute deterioration of the disease. The time until partial response in the first case was 7 months and in the second case 12 months. Adverse events were slight, though a standard dose as a single drug was used for each drug. The treatment time course was shortened because capecitabine was an oral drug. Therefore, this combination therapy was expected to maintain high quality of life and obtain a high response rate.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Monoclonal / therapeutic use*
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Biomarkers, Tumor / blood
  • Bone Neoplasms / blood
  • Bone Neoplasms / diagnostic imaging
  • Bone Neoplasms / drug therapy
  • Bone Neoplasms / secondary
  • Breast Neoplasms / diagnostic imaging
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / pathology*
  • Capecitabine
  • Deoxycytidine / analogs & derivatives*
  • Deoxycytidine / therapeutic use
  • Female
  • Fluorouracil / analogs & derivatives*
  • Fluorouracil / therapeutic use
  • Humans
  • Immunotherapy
  • Liver Neoplasms / blood
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / drug therapy
  • Liver Neoplasms / secondary
  • Middle Aged
  • Neoplasm Staging
  • Recurrence
  • Tomography, X-Ray Computed
  • Trastuzumab

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Biomarkers, Tumor
  • Deoxycytidine
  • Capecitabine
  • Trastuzumab
  • Fluorouracil