T-cell receptor isoforms and signal transduction

Curr Opin Immunol. 1991 Feb;3(1):32-9. doi: 10.1016/0952-7915(91)90073-a.

Abstract

Recent cDNA and genomic cloning have identified CD3 eta as an alternatively spliced product of the same gene locus that encodes CD3 zeta. Three distinct T-cell receptor isoforms have now been identified. A current view of the signal transduction function of these isoforms in thymocytes and T cells is discussed.

Publication types

  • Review

MeSH terms

  • Antigens, Differentiation, T-Lymphocyte / biosynthesis
  • Antigens, Differentiation, T-Lymphocyte / genetics
  • CD3 Complex
  • Calcium / metabolism
  • Phosphatidylinositols / metabolism
  • Protein Biosynthesis
  • Protein-Tyrosine Kinases / metabolism
  • RNA Processing, Post-Transcriptional
  • Receptors, Antigen, T-Cell / biosynthesis
  • Receptors, Antigen, T-Cell / genetics
  • Receptors, Antigen, T-Cell / immunology*
  • Signal Transduction / immunology*
  • Transcription, Genetic

Substances

  • Antigens, Differentiation, T-Lymphocyte
  • CD3 Complex
  • Phosphatidylinositols
  • Receptors, Antigen, T-Cell
  • Protein-Tyrosine Kinases
  • Calcium