Abstract
Trospectomycin is an aminocyclitol analog of spectinomycin with significant in vitro activity against Chlamydia trachomatis. A single 1-g intramuscular dose was administered to 10 men with symptomatic, culture-positive chlamydial urethritis. Trospectomycin was well tolerated but failed to eradicate chlamydial infection, as determined by cultures obtained approximately 1 week after treatment.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Anti-Infective Agents / administration & dosage
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Anti-Infective Agents / therapeutic use*
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Chlamydia Infections / drug therapy*
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Chlamydia Infections / microbiology
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Humans
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Injections, Intramuscular
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Male
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Middle Aged
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Spectinomycin / administration & dosage
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Spectinomycin / analogs & derivatives*
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Spectinomycin / therapeutic use
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Urethritis / drug therapy*
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Urethritis / microbiology
Substances
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Anti-Infective Agents
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trospectomycin
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Spectinomycin