The high producer variant of the Fc-receptor like-3 (FCRL3) gene is involved in protection against multiple sclerosis

J Neuroimmunol. 2008 Mar;195(1-2):146-50. doi: 10.1016/j.jneuroim.2008.01.004. Epub 2008 Mar 3.

Abstract

Some polymorphisms in the FCRL3 gene, a member of the Fc-receptor like family, have been associated with several autoimmune diseases and recently with multiple sclerosis (MS). We performed a case-control study of three SNPs in FCRL3 gene in 645 MS patients and 786 controls, all Caucasians from the South of Spain. Genotype and allele frequencies of two SNPs (rs7528684/FCRL3_3 and rs7522061/N28D), which were in high linkage disequilibrium (r(2) = 0.87), differed between MS cases and controls. The C allele of FCRL3_3 was found to be protective for MS (per allele OR = 0.81, 95% C.I. = 0.70-0.94; P-value = 0.007) as was the G variant of N28D, but no association was found for rs11264799/FCRL3_4. Haplotype analysis confirmed these associations with highly consistent effect sizes for haplotypes carrying the C allele of FCRL3_3.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asparagine / genetics
  • Aspartic Acid / genetics
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Linkage Disequilibrium
  • Male
  • Multiple Sclerosis / genetics*
  • Multiple Sclerosis / prevention & control*
  • Polymorphism, Single Nucleotide / genetics*
  • Receptors, Immunologic / genetics*
  • Receptors, Immunologic / metabolism*
  • Spain
  • Statistics, Nonparametric

Substances

  • FCRL3 protein, human
  • Receptors, Immunologic
  • Aspartic Acid
  • Asparagine